Co-codamol 30 mg/500 mg

Product Overview Co-codamol 30 mg/500 mg is a prescription combination analgesic containing codeine phosphate 30 mg (an opioid pain reliever) and paracetamol 500 mg (acetaminophen). It is used for the short-term relief of moderate to severe acute pain in adults and children over 12 years when other painkillers (such as paracetamol or ibuprofen alone) are ineffective. Codeine works by binding to opioid receptors to reduce pain perception, while paracetamol helps relieve pain and fever.

Important Warning This medicine contains codeine, an opioid with high potential for addiction, tolerance, dependence, misuse, and withdrawal. It should only be used for short-term treatment (typically no more than 3 days). Prolonged or regular use can lead to addiction. Risk of life-threatening respiratory depression (slow/shallow breathing), especially when combined with alcohol, other opioids, or CNS depressants. Overdose can cause severe liver damage from paracetamol or fatal opioid effects. Do not exceed the recommended dose or take with other paracetamol-containing products. Always follow your doctor’s instructions precisely.

Dosage and Administration

• Adults: 1–2 tablets every 4–6 hours as needed. Maximum 8 tablets (240 mg codeine/4,000 mg paracetamol) in 24 hours.
• Children 12–18 years: Use only under medical supervision; lower doses may be needed.
• Elderly or patients with liver/kidney issues: Lower dose recommended; consult doctor.
• Take with or without food, preferably with water.
• Do not use for more than 3 days without medical advice. If pain persists, see your doctor.
• Do not stop abruptly after prolonged use—taper under supervision to avoid withdrawal.

Common Side Effects

• Constipation, nausea, or vomiting
• Drowsiness, dizziness, or headache
• Dry mouth or sweating

Serious side effects (seek immediate medical help): Slow/shallow breathing, confusion, severe drowsiness, small pupils, allergic reactions (rash, swelling, breathing difficulty), severe skin reactions, seizures, or signs of overdose (e.g., liver damage symptoms like yellowing skin).

Precautions and Contraindications

• Do not use if you have: Hypersensitivity to codeine/paracetamol, severe respiratory issues, acute asthma attack, children under 12 years, recent tonsil/adenoid removal (risk of sleep apnea), severe liver disease, or if taking MAOIs (within 14 days).
• Avoid alcohol and other CNS depressants (e.g., benzodiazepines, opioids)—can cause severe respiratory depression, coma, or death.
• Caution with flucloxacillin (risk of metabolic acidosis).
• Not recommended during pregnancy (risk to fetus) or breastfeeding (codeine passes into milk; risk of infant respiratory depression).
• May impair driving or operating machinery—do not drive if affected.
• Use caution in elderly due to higher risk of falls, confusion, and respiratory issues.

Storage Store below 25–30°C in a cool, dry place away from light and moisture. Keep out of reach of children.

Note: This information is for general guidance. Always consult your doctor or pharmacist for personalized advice, and read the patient information leaflet provided with your medication. Co-codamol 30/500 should only be used when prescribed.