Lorazepam IP 2 mg (LOR – 2)

Product Overview Lorazepam 2 mg is a prescription medication belonging to the benzodiazepine class. It acts as an anxiolytic (anti-anxiety agent) with sedative, hypnotic, and muscle relaxant properties. It is primarily used for the short-term management of severe anxiety disorders, anxiety associated with depression, or anxiety-related insomnia. Lorazepam works by enhancing the effects of a natural chemical called GABA in the brain, producing a calming effect.

Important Warning This medicine is intended for short-term use only (typically 2–4 weeks maximum, including tapering). Prolonged use can lead to tolerance, dependence, addiction, and severe withdrawal symptoms. It is a controlled substance with high potential for abuse and misuse. Concomitant use with opioids can cause profound sedation, respiratory depression, coma, or death. Always follow your doctor’s instructions precisely.

Dosage and Administration

• Adults (for anxiety): Initial dose 2–3 mg daily in divided doses (e.g., 1–2 mg two or three times daily). Maintenance: 1–2 mg daily. Total daily dose usually 2–6 mg, rarely up to 10 mg.
• For insomnia due to anxiety: 2–4 mg taken as a single dose at bedtime.
• Elderly or debilitated patients: Start with lower doses (e.g., 1–2 mg daily in divided doses; initial dose should not exceed 2 mg) due to increased risk of side effects.
• Take with or without food.
• Do not stop suddenly—taper off gradually under medical supervision to avoid rebound anxiety, seizures, or withdrawal.

Common Side Effects

• Drowsiness, sedation, or fatigue
• Dizziness, weakness, or unsteadiness
• Confusion, memory impairment, or headache
• Muscle weakness or ataxia

Serious side effects (seek immediate medical help): Slow/shallow breathing, severe drowsiness, unusual behavior changes (e.g., aggression, hallucinations), depression, suicidal thoughts, or signs of allergic reaction (rash, swelling).

Precautions and Contraindications

• Do not use if you have: Acute narrow-angle glaucoma, severe respiratory insufficiency, sleep apnea syndrome, severe liver impairment, myasthenia gravis, known hypersensitivity to benzodiazepines, or history of drug/alcohol dependence.
• Avoid alcohol and other CNS depressants (e.g., opioids, sedatives)—can cause life-threatening respiratory depression.
• Not recommended during pregnancy (risk of fetal harm, including congenital malformations) or breastfeeding (passes into breast milk).
• May impair driving or operating machinery—do not drive if affected.
• Use extreme caution in elderly patients due to increased risk of falls, confusion, cognitive impairment, and fractures.

Storage Store below 30°C (or at room temperature 20–25°C) in a cool, dry place away from children. Protect from light and moisture.

Note: This information is for general guidance. Always consult your doctor or pharmacist for personalized advice, and read the patient information leaflet provided with your medication. Lorazepam should only be used when prescribed.